Paint.Net 5.0 is a major new release that 'has many major performance improvements, new features including pressure sensitivity for pens and drawing tablets, and a brand new effect plugin system with GPU rendering support' according to the author of Paint.Net. Older versions of Windows are no longer supported, and users who still run these devices may keep on running 4.x instead. The new version runs only on 64-bit versions of Windows 10 and 11.
Paint.Net 5.0 is a new major release that makes changes to the program's system requirements.